It used to be marketed under the name tylose, a registered. Preparation of carboxymethyl cellulose cmc from microcrystalline cellulose was carried out by an etherification process, using naoh and monochloroacetic acid mca. When combined with water and other substances such as propylene glycol, sodium carboxymethyl forms a eutectic mixturea mixture whose freezing point is lower than that of any of the mixture constituents. Without a disintegrant, tablets may not dissolve appropriately and may effect the. Blanose sodium carboxymethyl cellulose aqualon 7l2p. Jul 06, 2015 sodium carboxymethyl cellulose cmc,e466 is used in food as a viscosity modifier or thickener, and to stabilize emulsions in various products. All our cmc brands are watersoluble polymers derived from cellulose and by choosing the right cellulose gum type, you can achieve the desired. It is made by reacting sodium monochloroacetate with alkalicellulose under rigidly controlled conditions. Aqualon cmct technical grades polymers are technical grades of sodium carboxymethylcellulose. Using sans, we establish that this polymer is molecularly dissolved in water with a locally stiff conformation with a stretching parameter.
Continue the stirring until a clear solution is produced. The cellulose was then converted to carboxymethyl cellulose cmc by mercization with various sodium hydroxide naoh concentrations and. Sodium carboxymethylcellulose scmc reevaluated for. Physical and chemical properties aqualon sodium carboxymethylcellulose. Manufacturing process of sodium carboxymethylcellulose. Carboxymethyl cellulose an overview sciencedirect topics. It acts as a thickener, binder, stabilizer, protective colloid. Sodium carboxymethyl cellulose is also used in toothpaste, laxatives, diet pills,waterbased paints, detergents, textile sizing, and various paper products. Aqualon and blanose mc are anionic, watersoluble polymers. Aqualon sodium carboxymethylcellulose cmc is made by reacting sodium monochloroacetate with alkalicellulose under rigidly controlled conditions.
Besides modifying the behavior of water, cellulose gum is useful in suspending solids and modifying the flow and texture. Sodium carboxymethyl cellulose, enzymatically hydrolysed cellulose gum, enzymatically hydrolyzed 469. Apr 05, 2005 wolff cellulosics is one of the major producers of purified and highly purified sodium carboxymethyl cellulose cmc. The anode is a hollow cylinder of powdered zinc set in a carboxymethylcellulose, polyacrylate or other polymerbased gel. If unconscious, place in recovery position and seek medical advice. Carboxymethyl cellulose cmc properties and applications. In skin care applications, it provides adhesion for quick tack and hold as well as lubricious aesthetics. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. Specification of sodium carboxymethyl cellulose for food. Disintegrants facilitate the breakup of a tablet in the intestinal tract after oral administration. Synthesis and characterization of carboxymethyl cellulose. Firstaid measures eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Carboxymethylcellulose an overview sciencedirect topics. Water resistance varies from excellent for benzyl cellulose to poor for methyl cellulose 7,8,31. Sodium carboxymethyl cellulose market global industry. Refresh tears lubricant carboxymethylcellulose sodium solution drops if this spl contains inactivated ndcs listed by the fda initiated compliance action, they will be specified as such. It acts as a thickener, binder, stabilizer, protective colloid, suspending agent, and rheology, or flow control agent. We report a small angle neutron scattering sans and rheology study of cellulose derivative polyelectrolyte sodium carboxymethyl cellulose with a degree of substitution of 1.
Degree of substitution is an important factor influencing water solubility and the viscosity of. Carboxymethyl cellulose, sodium salt revision date 19jan2018 sodium carboxymethyl cellulose 9004324 100 4. Type of ds substitution limits sodium rate, % 7 a 0. Pdf preparation of carboxymethyl cellulose from corncob. Sodium carboxymethyl cellulose is a organic compound manufactured through chemical synthesis. Then, a carboxymethyl cellulose sodium alginatechitosan composite. Find patient medical information for carboxymethylcellulose sodium bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Us9181659b2 compositions having increased concentrations of. A variety of cmc grades are available, with varying degrees of substitution, viscosities and particle sizes. Carboxymethyl cellulose cmc is the major cellulose ether. Find patient medical information for carboxymethylcellulose sodium ophthalmic eye on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Walocel c uspep carboxymethyl cellulose sodium for. Structure of sodium carboxymethyl cellulose aqueous. It is available in a variety of viscosity ranges and degrees of substitution. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Aqualon cellulose gum has the ability to form strong, oilresistant films. Hydroxy ethyl cellulose and sodium carboxy methyl cellulose can also be used as thickeners. It is often used as its sodium salt, sodium carboxymethyl cellulose. Purified cmc for personal care and cosmetic applications is typically sold at 99. The active substances form a mixture that is incorporated in articles such as pads, trays, lids.
It is insoluble in organic solvents such as methanol, alcohol, diethyl ether, acetone, chloroform and benzene but soluble in water. I have tried to dissolve carboxymethylcellulose sodium. Aqualon cmc 7l sodium carboxymethylcellulose tm trademark, ashland or its. Sodium carboxymethylcellulose scmc university of michigan. Trademark cpr and the msds contains all the information required by the cpr. The bound carboxymethyl groups ch 2cooh along the polymer chain makes the cellulose watersoluble. Figure 4 shows the effects on friction factor of different concentrations of bovine serum and whilst metalonmetal joints are helped by adsorbed proteins, ceramiconceramic joints are hindered by the presence of such a large protein attached to the surface which is only separated from its opposing surface by a fluid film of 0. Sodium carboxymethyl cellulose cmc a professional supplier of sodium carboxymethyl cellulose in china. Wo2005089715a1 ophthalmic solution comprising sodium. Us5932193a toothpaste compositions containing fluidized. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as.
This solution was then combined with a sodium carboxymethyl cellulose solution and the mixture was cast onto a glass plate and dried at a constant temperature of 60 c. We have extensive knowledge of the cmc manufacturing process and the products. Aqualon sodium carboxymethylcellulose by ashland specialty chemical acts as a lubricant abd thickening agent. Sodium carbox ymethylcellulose scmc re evaluated for paper, book, papyrus, and parchment conserv ation abstract the cellulose ether, s odium carboxymethylcellulose scmc, has long been used in england as an allpurpose adhesive, consolida nt, and sizing agent, while its conservation use in the united states has been limited. Once this happens, the cellulose is then reacted with sodium monochloroacetate to yield sodium carboxymethyl cellulose. Sodium carboxymethyl cellulose msds, sodium carboxymethyl.
Aqualon cellulose gum is the sodium salt of carboxymethylcellulose especially purified to a minimum assay of 99. The rheological behaviors of cmc solutions of different molecular mass. The resultant anionic polymer is purified and dried. The crosslinking reduces water solubility while still allowing the material to swell like a sponge and absorb many times. Aqualon sodium carboxymethylcellulose ashland specialty. China sodium carboxymethyl cellulose cmc manufacturers. Aqualon cellulose gum, or sodium carboxymethylcellulose cmc, is widely used as an economical thickener and stabilizer in foods and beverages. By activating the noncrystalline regions of cellulose, selective regions of alkylating reagents can attack the cellulose.
Sodium carboxymethyl cellulose in pharmaceutical industry. Blanose sodium carboxymethyl cellulose aqualon 7l2p compare products. Sodium carboxymethylcellulose is an important cellulose ether, it is obtained by chemical modification of natural fiber and is a polyanion compound with good watersolubility, easily soluble in both cold and hot water, sodium carboxymethylcellulose has many unusual and valuable physical and chemical characteristics such as emulsifying disparity, solid disparity. Sodium carboxymethyl cellulose not listed as a carcinogen by acgih, iarc, ntp, or ca prop 65. Synthesis and characterization of carboxymethyl cellulose cmc from water hyacinth using ethanolisobutyl alcohol mixture as the solvents. Disclosed are toothpaste compositions and a process for preparing such compositions comprising dental abrasive, humectant, fluidized polymer suspension and a suitable vehicle for the humectant, wherein the fluidized polymer suspension comprises. Carboxymethyl cellulose, also known as cmc or cellulose gum, has been a part of our product portfolio since the early 1940s. It increases viscosity, serves as a suspension aid 4, and stabilizes emulsions 5. Carboxymethyl cellulose cmc or cellulose gum is a cellulose derivative with carboxymethyl groups ch 2cooh bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone. Cmc is made by reacting alkali cellulose with sodium monochloroacetate under rigidly controlled conditions. Sodium carboxymethyl cellulose definition is a gummy substance that is obtained as a hygroscopic powder or a granular solid by reaction of alkali cellulose and sodium chloroacetate, that is either soluble in water or swells in water, and that is used chiefly as a thickening, emulsifying, and stabilizing agent as in sizes for textiles and paper and in pharmaceutical ointments and as a bulk.
Aqualon sodium carboxymethylcellulose, physical and chemical properties, hercules, inc. Applications and properties of sodium carboxymethyl cellulose. Aqualon cmc 7l sodium carboxymethylcellulose trademark, ashland or its subsidiaries, registered in various countries 431161 version. Pdf physical and chemical properties aqualon sodium. Sep 06, 2019 carboxymethyl cellulose msds pdf aqualon cmc 7l sodium carboxymethylcellulose. Cellulose, carboxymethyl ether, sodium salt product safety information. Sodium carboxymethyl cellulose definition of sodium. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. A cellulose derivative which is a beta1,4 dglucopyranose polymer.
Ashland offers a wide range of excipients which includes aqualon sodium carboxymethylcellulose. Sodium carboxy methyl cellulose is a thickening agent. Aqualon 7lf is a highly purified sodium carboxymethylcellulose. Carboxymethylcellulose sodium cmc, is widely used as an excipient in oral, topical, and parenteral pharmaceutical formulations. Our products are marketed under the brand names of walocel crt a cellulose gum and walocel crt in more than 70 countries around the world. The authors are with the department of chemical engineering, universitas indonesia, depok 16424, indonesia email. We make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.
Aqualon sodium carboxymethylcellulose ashland cphi online. The cellulose ethers have fair to good resistance to dry heat. Carboxymethyl cellulose cmccellulose gum cp kelco, a. A 38 % of cellulose was successfully extracted from sugarcane bagasse through alkali treatment followed by the nitric acid hydrolyzed process.
An aqueous suspension comprising at least 8 % by weight of watersoluble carboxymethylcellulose, characterized in that the suspension also comprises an at least 33 %, by weight solution of potassium carbonate in water. Carboxymethyl cellulose is known for its excellent water retaining capacity. Skin contact wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Pawlak a the effect of cellulase treatments on the rheology of carboxymethyl cellulose cmc solutions was studied using a rotational viscometer. An anionic watersoluble polymer derived from cellulose, it has the following functions and properties. The recommended scmc is aqualon cellulose gum cmc 7h3sf pha pharmaceutical quality, highviscositygrade scmc. Find out more about cellulose gum cosmetic ingredient, all the commercially available products, formulation examples and other related technical info. The presence of co bond at wavenember of 1606 1632 cm1 in infrared radiation ir spectrum confirmed the conversion of cellulose to carboxymethyl cellulose. Aqualon sodium carboxymethylcellulose cmc has a minimum purity of 99. This carboxymethylcellulose thickens aqueous systems and is used in personal care products for water binding, syneresis control, and its ability to suspend pigments and active ingredients in solution. Aqualon blanose, bondwell sodium carboxymethylcellulose cmc is utilized in multiple markets including adhesives and sealants, advanced ceramics, building and construction, ceramics, pottery and porcelain, commercial and institutional, housewares and consumer, medical, metal castings and foundry, mining and extraction, pulp and paper, textiles and tobacco. This is termed the concept of reactive structure fractions and is used widely for the production of cmc.
Soluble, associative carboxymethylcellulose, method of making, and uses thereof. See actual entry in rtecs for complete information. Carboxymethyl cellulose 12 in accordance with usp has sodium content of not less than 10. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed. Trademark, ashland or its subsidiaries, registered in various countries. Preparation of carboxymethyl cellulose cmc from microcrystalline cellulose was carried out by an etherification process, using naoh and monochloroacetic acid mca, with ethanol and water as the. Physical and chemical properties of cmc physical properties sodium carboxymethyl cellulose cmc an anionic cellulose ethers, the appearance is white or slightly yellow flocculent fiber powder or white powder, odorless, tasteless, nontoxic. The usp grade of cellulose gum destined for pharmaceutical and. It is used for water binding and syneresis control. Material safety data sheet carboxymethyl cellulose, sodium.
Oct 18, 2012 this scientific opinion of efsa deals with the risk assessment of the active substances sodium carboxymethylcellulose, bentonite and aluminium potassium sulphate dodecahydrate, cas no 9004324, 2789 and 7784249 respectively. Cellulose, carboxymethyl ether, sodium salt product safety. Sodium carboxy methyl cellulose scmc suhal cellulose llp. Sodium carboxymethyl cellulose forms films that are resistant to oils, greases, and organic solvents.
Dailymed refresh tears lubricant carboxymethylcellulose. Aqualon sodium carboxymethylcellulose, physical and chemical properties, hercules incorporated, 1998. In the pharmaceutical industry, sodium carboxymethyl cellulose can be used as emulsion stabilizer of injections, the adhesion and filmforming agents of tablets. Sodium carboxymethylcellulose, bentonite, aluminium potassium. Sodium carboxymethyl cellulose applications, sodium. An ophthalmic solution comprising a hydrogen peroxide source in an amount sufficient to result in between about 0.
Aqualon cellulose gum, or sodium carboxymethylcellulose cmc, is widely used as an economical. Sodium carboxymethylcellulose is an important cellulose ether, it is obtained by chemical modification of natural fiber and is a polyanion compound with good watersolubility, easily soluble in both cold and hot water, sodium carboxymethylcellulose has many unusual and valuable physical and chemical characteristics such as emulsifying disparity, solid disparity, resistance to decay, being physiologically harmless etc. Sodium carboxymethyl cellulose is sometimes used to make reusable ice packs. Cellulose gum carboxymethyl cellulose cosmetic ingredient. Aqualon co original assignee aqualon co priority date the priority date is an assumption and is not a legal conclusion. Apr 01, 2015 we report a small angle neutron scattering sans and rheology study of cellulose derivative polyelectrolyte sodium carboxymethyl cellulose with a degree of substitution of 1. Sodium carboxymethylcellulose scmc reevaluated for paper. Sodium carboxymethyl cellulose is used as a viscosity modifier or thickener, and to stabilize emulsions in various products including consumer goods.
Aqualon 9m8f pharma is a highly purified sodium carboxymethylcellulose. The pure sodium carboxymethyl cellulose is white or milk white fibrous powder or particles, odorless and tasteless. In order to promote public education and public safety, equal justice for all, a better informed citizenry, the rule of law, world trade and world peace, this legal document is hereby made available on a noncommercial basis, as it is the right of all humans to know and speak the laws that govern them. The aqualon division of hercules refers to their mc and mhpc products by the trade name. Preparation of sodium carboxymethyl cellulose from paper sludge. Viscosity properties of sodium carboxymethylcellulose solutions. More recently, applications for cmc in formulations that facilitate improved delivery of cytotoxic drugs and biologics have been evaluated 6, 7. Structure of sodium carboxymethyl cellulose aqueous solutions. When dissolved, it increases the viscosity of aqueous solutions, suspensions and. Carboxymethylcellulose sodium appears as white, fibrous, freeflowing powder, and is used commonly as an fdaapproved disintegrant in pharmaceutical manufacturing. Carboxymethyl cellulose c6h7ooh3 xoch2coohxn is a derivative of the regenerated cellulose c6h10o5n with hydroxyacetic acid hydroxy ethanoic acid ch2ohcooh or sodium monochloroacetate clch2coona. Sodium carboxymethyl cellulose cmc in food industry.
All walocel c grades comply with the carmellose sodium. Cmcna is a white fibrous or granular powder, odorless, tasteless, hygroscopicity, easy to disperse in the water form a transparent colloidal solutions. I dissolve about 2% of carboxymethyl cellulose in water but i cant get a homogeneous liquid because the cmc separate from water. Zinc powder with median particle diameters in the range 150250.
Ca2503507c soluble, associative carboxymethylcellulose. Carmellose sodium cellulose, carboxymethyl ether, sodium salt sodium carboxymethylcellulose carboxymethylcellulose, sodium salt cellulose sodium glycolate. Section 12 ecological information section disposal considerations dispose of in a manner consistent with federal, state, and local regulations. Request pdf viscosity properties of sodium carboxymethylcellulose solutions through viscosity measurements, concentration and temperature dependences. Animal experiments have shown that sodium carboxymethyl cellulose is a safe and reliable carrier of anticancer drugs. Aqualon 9m8f ph is cellulose gum and is widely used as an economical thickener and stabilizer in tablet binding and tablet film coating applications. Rheology of carboxymethyl cellulose solutions treated with cellulases jung myoung lee a, john a.
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